B-Elementary

Although Raman microscopes have been improved over the years to provide easier particle analysis and a degree of automation,  the drawbacks remain. We bring you BRAVE B-Elementary which takes you a giant leap forward so you can enjoy Raman spectra recorded continuously and in-flow on a single-particle basis with minimum sample preparation.

Raman analysis with minimal sample preparation

BRAVE B-Elementary takes the hassle out of Raman analysis of particles. Depending on your sample, you might not even need to filter before starting analysis. You just load the sample into the device and press Start. BRAVE B-Elementary is the perfect tool for gaining insights into large sample volumes, e.g. for non-target screening on groundwater samples. It opens the door to particle analytics like never before.

This is how BRAVE B-Elementary revolutionizes your particle analysis 

Anyone who has ever worked with conventional Raman microscopes knows that a lot of time is spent filtering the sample and applying it to the substrate. Results come at a cost and time spent on sample preparation would be better spent elsewhere. Wouldn’t it be great to eliminate tedious sample preparation and get straight to the chemical analysis part?

Enter BRAVE B-Elementary, the Raman analyzer which works directly from the sample vial and lets you analyze particles continuously and in-flow for minutes and even hours at a time. Sample is automatically pumped through the measuring cell, Raman spectra are recorded and the results delivered to your PC via the H.A.N.S. software. The number-based particle size and particle concentration of the sample are also determined.

With BRAVE B-Elementary you can:

• Get particle analytics at the touch of a button
• Increase your output while reducing sample preparation efforts
• Measure directly and continuously in sample flow
• Get results easily for many different substances in a sample
• Detect and read out substances even when they are at ultra-low concentrations
• Identify substances, phases and polymorphs in high-throughput screening

BRAVE particle analytics: one platform, many solutions 

BRAVE B-Elementary makes Raman analysis easier than ever before. Your sample analysis will run without you, meaning you are free to get on with other work

• Continuous analysis in-flow directly in liquids

• Minimal or no sample preparation required

• Ideal for high-throughput screening

• Automated analysis with minimum user interaction

• Results even when fluorescence is present (sample-dependent)

• Automatic cleaning cycle that saves you time and effort

• Raman analysis even on ultra-low concentrations

• Exact measurement of particle size, particle size distribution as well as particle concentration also available

• Future implementation into production processes as a PAT sensor

BRAVE B-Elementary is part of a modular platform 

The BRAVE devices are built as a modular platform, so you can configure your system to perfectly suit your needs. The basis and prerequisite for Raman analysis is the BRAVE B-Curious nanoparticle analyzer. Adding the BRAVE B-Elementary Raman module extends the platform. These other modules are currently being developed: module to detect and determine size of large-particle counts, Raman tweezers, automation and sample handling upgrades).

The BRAVE modules 

• Concentration determination: The BRAVE B-Curious device allows the detection and measurement of particles at ultra-low concentrations down to a few particles per milliliter.
• Time-resolved particle sizing & PSD: This additional module allows the monitoring of PSD continuously and directly out of containers. You can monitor sample behavior such as agglomeration, formation, dissolution, aggregation, dissociation, self-assembly and more. Detection range: 50 nm* to 5 µm* (*sample-dependent)
• Size range extension: This additional module allows the detection of large-particle tails, LPC, aggregation behaviors and anomalies. Detection range: 50 nm* to 50 µm* (*sample-dependent)
• Particle analytics: This module allows the identification and characterization of particle populations via Raman spectroscopy.
• Low-volume sizing: This module allows the determination of particle size and PSD from low volumes, starting at 20 µl (sample-dependent)
• Raman tweezers: This module allows the trapping of particle populations for characterization with Raman spectroscopy.

Applications: BRAVE B-Elementary in action 

BRAVE B-Elementary is ideal for routine chemical analysis for non-specialists.
For people with application knowledge it is an excellent tool for gaining explorative insights.

Applications for BRAVE B-Elementary

• Detection and identification of microplastics in water
• Identification of unwanted aggregates during the production of monoclonal antibodies (mAbs)
• Non-targeted screening
• Identification of contamination in production plants
• Quality control on ultra-pure water
• Gaining insights into soil composition
• Research into medicines, e.g. vaccines and nanocarriers
• Waste water analysis