B-Curious

Investigate nanoparticles like never before with BRAVE B-Curious

Do you want to make ground breaking discoveries and gain deep insights into your samples? BRAVE B-Curious is the ideal nanoparticle analyzer to achieve this. Get nanoparticle characterization results like never before!

Conventional methods of particle analysis like DLS, NTA or Laser Diffraction only show a fraction of what the revolutionary technology of BRAVE B-Curious can measure.

The patented OF2i® method provides detailed insights into all particle populations within your sample. It tracks changes in nanoparticle size distributions and particle concentrations continuously and in real-time. With this nanoparticle analyzer, you gain a better understanding of particle behaviour and process dynamics. All measurement results are  statistically relevant. B-Curious helps you elevate your search to a new level.

Features of the nanoparticle analyzer:

• Benchtop nanoparticle analyzer for particle concentration measurement and continuous, time-resolved nanoparticle characterization for the laboratory
• Quicker than conventional methods
• Measures continuously and in real-time; proven throughput up to 1000 particles/minute
• 100 % representative results, even for complex, polydisperse systems
• An automated self-cleaning cycle takes approx. 30 seconds
• Detection range: 50 nm* to 5 µm* (*sample-dependent, smaller sizes on request, large-particle module up to 50 µm is planned)
• The possibility to use the same method in the lab as is used for online production monitoring, e.g. of nano emulsions (PAT sensor)

The B-Curious allows continuous, real-time analysis of particle behavior over extended periods. Its single-particle sensitivity enables the measurement of up to 1,000 particles per minute. This ensures the results are statistically relevant and representative of the entire particle population.

With this time-resolved approach, you can monitor kinetic processes such as aggregation, condensate formation, agglomeration, dissolution or dissociation. These processes can be analyzed in real-time and within a single continuous measurement.

BRAVE B-Curious allows you to:

• Observe changes in nanoparticle size distribution in real-time
• Obtain new insights into your sample, in a continuous, time-resolved measurement
• Better understand sample kinetics and document changes and interactions
• Get representative results that give a complete picture of your sample composition
• Detect and capture ultra-low concentrations and get statistically relevant results
• Obtain measurement data much faster

The B-Curious is a modular platform

The B-Curious is designed as a modular platform, allowing you to configure it precisely to your needs. Our experts collaborate with you to create a custom-tailored setup that fits your specific application. Your BRAVE B-Curious will be tailored to your specific needs and optimized for your research. It also offers the flexibility for future upgrades and additional modules as your requirements evolve.

The BRAVE modules

• Module for concentration determination: Allows the detection of ultra-low concentrations (e.g. nano plastics or water for injections) at particle concentrations down to a few particles per millilitre.
• Module for time-resolved sizing: Allows the monitoring of PSD continuously and directly out of containers. This way you can monitor sample behaviour such as agglomeration, formation, dissolution, aggregation, dissociation, self-assembly and more. Detection range: 50 nm* to 5 µm* (*sample-dependent)
• Module for size range extension: Allows the detection of large-particle tails, LPC, aggregation behaviours and anomalies. Detection range: 50 nm* to 50 µm* (*sample-dependent)
• Module for particle analytics: Allows the identification and characterization of particle populations via Raman spectroscopy. Adding this module makes a BRAVE B-Elementary device.
• Module for low-volume sizing: Allows the determination of PSD from low volumes, starting at 20 µl (sample-dependent)
• Module for Raman tweezers: Allows the trapping of particle populations for characterization with Raman spectroscopy. Adding this module makes a BRAVE B-Elementary device.

H.A.N.S. – the software for BRAVE B-Curious

H.A.N.S. (High-throughput Analysis Nano-characterization Software) is installed on the BRAVE B-Curious products. The H.A.N.S. software is structured and straightforward. All workflows are intuitive to use. The software allows individual application and method development and comes with preset and definable device parameters.

The software contains three main control assets:

• Instrument control
• Data analysis
• Data management, conversion and transfer

H.A.N.S. supports you with:

• Export of raw data as CSV and as a complete, user-defined protocol
• Flexible data transfer to your LIMS or SPC software
• Various interface options
• Remote support and updates via your network

This is how OF2i® raises your research to a new level

BRAVE B-Curious implements a new approach to particle analysis: OF2i®. This new principle of particle characterization uses opto-fluidic forces to accelerate, decelerate, trap or even redirect nanoparticles. OF2i® (OptoFluidic Force Induction) allows you to measure particle size, particle size distributions and particle concentrations more exactly than ever before – with single-particle sensitivity and statistical relevance. Unlike established methods, the  patented OF2i® method is not dependent on Brownian motion. With OF2i® you measure continuously and in real-time and can even resolve complex, polydisperse systems.

• As OF2i® is not dependent on measuring Brownian motion it delivers measurement results instantaneously
• OF2i® measures up to 1000 particles per minute continuously to deliver statistically relevant values
• OF2i® measures with single-particle sensitivity and delivers D-values and particle size distribution (PSD curves) based on actual measurements without averaging or extrapolation
• The OptoFluidic Force Induction method is capable of detecting large-diameter particles, low-particle counts, particle tails, anomalies and other outliers