B-Continuous

Take your production to the next level with BRAVE B-Continuous 

Revolutionize your production processes like never before. Save time and resources as well as reduce out-of-spec production and increase efficiency.

BRAVE B-Continuous is the first true PAT sensor for real-time online nanoparticle characterization. It monitors particle size, number-based particle size distributions and particle concentration during production  while delivering measurements directly to your network. Thanks to BRAVE B-Continuous, waiting for the results from  samples sent to the lab is reduced to a minimum. This sensor lays the foundation for real-time release testing

Features: 

• Direct and easy integration to your production plant as an online PAT sensor
• Seamless measurement data in real-time 24/7
• Reliable and representative data with single-particle sensitivity
• Detection of large-particle tails, aggregates and anomalies
• Precise measurement of particle size, particle size distribution and particle concentration
• Basis for Real-Time Release Testing
• Important insights for predictive maintenance of your production plant
• Perfect documentation of measurement results

This is how BRAVE B-Continuous revolutionizes your production as an online PAT sensor 

As BRAVE B-Continuous can be easily embedded into your production plant as a fully automated PAT sensor, you can monitor your production continuously and in real-time. This way you obtain exact measurement data regarding particle size, number-based particle size distribution and particle concentration without the need to rely on sample analysis from the laboratory. With the continuous measurement data from BRAVE B-Continuous you can optimize and adapt your production constantly.

With BRAVE B-Continuous:

• You can reduce rejects as you now have total control of the particle sizes and are able to continuously monitor and adjust them.
• You don’t need to wait for lab test results and can optimize your processes in real-time. Measurement data is visible on your network in a matter of seconds.
• You obtain a better understanding of your production processes, as you constantly collect precious data for process optimization.
• You are able to monitor the health of your production plant and carry out maintenance in good time.
• You ensure the quality of your final product, as anomalies, aggregates and oversized particles will be identified.
• You can integrate checks on the filtration and dilution systems
• You establish a basis for RTRT (Real-Time Release Testing).
• You can fully concentrate on your other duties knowing that your production is doing as it should and the quality of your product is guaranteed.

Monitor and control your production processes 

The monitoring and control of production processes reach new heights with BRAVE B-Continuous: it provides single-particle sensitivity, delivers complete sizing histograms and even detects large-particle counts. Interim testing of your samples in the lab loses its urgency; you can rely on BRAVE B-Continuous to minimize the risk of out-of-spec production.

BRAVE B-Continuous in action

Increase production efficiency with BRAVE B-Continuous 

All of these benefits are possible because OF2i ® BRAVE’s new, patented method for particle size measurement is not restricted by the limits set by Brownian motion. Instead OF2i® (link open in new tab) uses optofluidic forces and actively transfers momentum to nanoparticles by laser, so the intensity of the scattering and the movement of a single particle as well as the number of particles per transported volume can be measured by an ultramicroscope. This leads to significant advantages for the online measurement of particle size, particle size distribution and particle concentration compared to conventional methods for analyzing nanoparticles.

• As OF2i® is not dependent on measuring Brownian motion it therefore delivers measurement results instantaneously
• OF2i® measures up to 3000 particles per minute continuously to deliver statistically relevant values
• OF2i® measures with single-particle sensitivity and delivers D-values and particle size distribution (PSD curves) based on actual measurements without averaging or extrapolation
• The OptoFluidic Force Induction method is capable of detecting large-diameter particles, low-particle counts, particle tails, anomalies and other outliers

H.A.N.S. – the software for BRAVE B-Continuous 

This software controls the PAT sensor and delivers measurement reports. H.A.N.S. has understandable workflows and intuitive interfaces as well as preset and definable device parameters for individual application and method development.

H.A.N.S. protects, analyzes and reports your data

H.A.N.S. connects to laboratory information management systems (LIMS) and other industrial process control interfaces like the Message Queuing Telemetry Transport (MQTT) standards. He supports you in your daily work:

• User control and measurement logs towards 21 CFR Part 11 compliance are already included
• Measuring protocol as a PDF (signed and tamper-proof for full data integrity)
• Secure data transfer with signature verification

H.A.N.S. provides more:

• Access to raw data in CSV format
• Additional features available via OTA (over the air) update
• Remote support and updates via your network