B-Curious

Investigate nanoparticles like never before with BRAVE B-Curious

Do you want to make groundbreaking discoveries and gain deep insights into your samples? With BRAVE B-Curious you have the perfect tool for these discoveries. Get nanoparticle characterization results like never before.

Conventional methods of particle analysis like DLS, NTA or Laser Diffraction only show a fraction of what the revolutionary technology of BRAVE B-Curious can measure.

The patented OF2i® method gives you detailed insights into all the particle populations of your sample and tracks changes in nanoparticle size distributions and particle concentrations in real-time and continuously. You will get a better understanding of particle behavior and learn more about the processes. All measurement results are representative and statistically relevant. As a true pioneer you can raise your research to a new level with BRAVE B-Curious.

Features:

• Benchtop nanoparticle analyzer for particle concentration measurement and continuous, time-resolved nanoparticle characterization for the laboratory
• Quicker than conventional methods
• Measures continuously and in real-time; proven throughput up to 1000 particles/minute
• 100 % representative results, even for complex, polydisperse systems
• An automated self-cleaning cycle takes approx. 30 seconds
• Detection range: 50 nm* to 5 µm* (*sample-dependent, smaller sizes on request, large-particle module up to 50 µm is planned)
• The possibility to use the same method in the lab as is used for online production monitoring, e.g. of nanoemulsions (PAT sensor)

The B-Curious lets you analyze particle behavior continuously and in real-time over minutes and hours. The results have single-particle sensitivity based on measurement of up to 1000 particles per minute. This makes them statistically relevant and representative of the whole particle population.  With this time-resolved approach you can monitor kinetic processes like aggregation, condensate formation, agglomeration, dissolution or dissociation and analyze them in real-time and in one continuous measurement.

BRAVE B-Curious allows you to:

• Observe changes in nanoparticle size distribution in real-time
• Obtain new insights into your sample, in a continuous, time-resolved measurement
• Better understand sample kinetics and document changes and interactions
• Get representative results that give a complete picture of your sample composition
• Detect and capture ultra-low concentrations and get statistically relevant results
• Obtain measurement data much faster

The B-Curious is a modular platform

The B-Curious is built as a modular platform, so you can configure it to perfectly suit your needs. Our experts will work together with you on a custom-tailored setup. Your BRAVE B-Curious will be aligned with your needs and ideal for your research – with the possibility of future upgrades and additional modules at a later date.

The BRAVE modules

• Module for concentration determination: Allows the detection of ultra-low concentrations (e.g. nanoplastics or water for injections) at particle concentrations down to a few particles per milliliter.
• Module for time-resolved sizing: Allows the monitoring of PSD continuously and directly out of containers. This way you can monitor sample behavior such as agglomeration, formation, dissolution, aggregation, dissociation, self-assembly and more. Detection range: 50 nm* to 5 µm* (*sample-dependent)
• Module for size range extension: Allows the detection of large-particle tails, LPC, aggregation behaviors and anomalies. Detection range: 50 nm* to 50 µm* (*sample-dependent)
• Module for particle analytics: Allows the identification and characterization of particle populations via Raman spectroscopy. Adding this module makes a BRAVE B-Elementary device.
• Module for low-volume sizing: Allows the determination of PSD from low volumes, starting at 20 µl (sample-dependent)
• Module for Raman tweezers: Allows the trapping of particle populations for characterization with Raman spectroscopy. Adding this module makes a BRAVE B-Elementary device.

H.A.N.S. – the software for BRAVE B-Curious

H.A.N.S. (High-throughput Analysis Nano-characterization Software) is installed on the BRAVE B-Curious products. The H.A.N.S. software is structured and straightforward. All workflows are intuitive to use. The software allows individual application and method development and comes with preset and definable device parameters.

The software contains three main control assets:

• Instrument control
• Data analysis
• Data management, conversion and transfer

H.A.N.S. supports you with:

• Export of raw data as CSV and as a complete, user-defined protocol
• Flexible data transfer to your LIMS or SPC software
• Various interface options
• Remote support and updates via your network

This is how OF2i® raises your research to a new level

BRAVE B-Curious implements a new approach to particle analysis: OF2i®. This new principle of particle characterization uses opto-fluidic forces to accelerate, decelerate, trap or even redirect nanoparticles. OF2i® (OptoFluidic Force Induction) allows you to measure particle size, particle size distributions and particle concentrations more exactly than ever before – with single-particle sensitivity and statistical relevance. Unlike established methods, the  patented OF2i® method is not dependent on Brownian motion. With OF2i® you measure continuously and in real-time and can even resolve complex, polydisperse systems.

• As OF2i® is not dependent on measuring Brownian motion it delivers measurement results instantaneously
• OF2i® measures up to 1000 particles per minute continuously to deliver statistically relevant values
• OF2i® measures with single-particle sensitivity and delivers D-values and particle size distribution (PSD curves) based on actual measurements without averaging or extrapolation
• The OptoFluidic Force Induction method is capable of detecting large-diameter particles, low-particle counts, particle tails, anomalies and other outliers